Characteristics of Commercial Effervescent Tablets Using Selected Pharmacopeial and Novel Analytical Methods

In the present study, we aimed to determine whether shelf life of effervescent tablets may be assessed during storage using total directional hemispherical reflectance (THR). We also analyzed selected pharmacopeial parameters and used X-ray microtomography assess internal structure tablets. Two types one commercial product containing magnesium vitamin B6 (expired unexpired) were analyzed. addition, randomly unexpired expired dried in a vacuum oven for 24 h at 50 °C. The disintegrated significantly shorter time than (68 s vs. 83 s, p = 0.016). remaining did not differ between two observed that showed lower mean values THR five spectral ranges, which indicates greater amount radiation beam was transmitted into their inner density on microtomographic scans differed all (p < 0.001). highest case (1.273 g/cm3), while lowest (1.261 g/cm3). had larger pore diameter compared (0.095 mm 0.074 mm, respectively; 0.007). Additionally, percentage porosity higher